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Severe hypersensitivity reactions, including anaphylaxis, generalized urticaria, and hypotension, tachycardia, and bronchospasm, have been reported following local instillation or injection of methylene blue

[DOI] [PMC free article] [PubMed] [Google Scholar] 193.Sharma V., Patial V

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[DOI] [PubMed] [Google Scholar] 75.Tobajas Y., Alemany-Forns M., Samarra I., Romero-Gimnez J., Tintor M., Del Pino A., Canela N., Del Bas J.M., Ortega-Oliv N., de Lecea C., et al

The major enzymes catalyzing forward S-glutathionylation reactions include GSTP1, GSTA4, and GSTO1, among which the role of GSTP1 was most recognized up to date

This amount is designed to prevent deficiency diseases like scurvy, but it is rarely enough to provide significant cosmetic or performance benefits