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JAK2/Y343/STAT5 signaling axis is required for erythropoietin-mediated protection against ischemic injury in primary renal tubular epithelial cells

Cell survival assays showed that EAG was 3 to 4.5-fold more cytotoxic to human cancer cells when compared to EA

The inflammation depends also on the impaired energy metabolism at the level of the mitochondria, which causes the activation of the microglia and the relative production of a plethora of pro-inflammatory mediators, including prostaglandins, cytokines, chemokines, complement, proteinases, reactive species of oxygen (ROS), and reactive species of nitrogen (RNS) [23,24]

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(60) However, studies are still inconclusive because increased activity of the ADH (ADH1*B2) enzyme and decreased activity of the ALDH (ALDH2*2) enzyme have also been described

Waghray M, Cui Z, Horowitz JC et al (2005) Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts