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Disruption of cAMP and prostaglandin E2 transport by multidrug resistance protein 4 deficiency alters cAMP-mediated signaling and nociceptive response

Tests were performed using GraphPad Prism version 7.0 software (GraphPad Software, San Diego, CA, USA)

Lecithin cholesterol acyltransferase

This cascade of events can create a vicious cycle, where increased oxidative stress leads to heightened HPA axis activity, which in turn perpetuates oxidative damage and mood dysregulation

each exerts distinct vascular effects