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Recent study revealed that the Tie2 signaling is attenuated by upregulated vascular endothelial protein tyrosine phosphatase in diabetic kidney in mice

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Because typical early atherosclerotic lesion formation observed in hyperhomocysteinemic animals can be prevented by an antiplatelet therapy with dipyridamole, the authors concluded that platelet-mediated proliferation of smooth muscle cells is a potential cellular mechanism involved in the atherogenicity of hyperhomocysteinemia
