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This study was a meta-analysis, so it did not require ethical approval from the institutional review board as well as the ethics committee

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The levels of COX-1 (Cat.No: 201-11-0909), COX-2 (Cat.No:201-11-0297), PGE2 (Cat.No: 201-11-0505) and PGI2 (Cat.No: 201-11-0503) were detected in the supernatants of tissue homogenates by ELISA kits, by following the instructions of the manufacturer (SunRed, PRC)

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PSEN1 Promoter Demethylation in Hyperhomocysteinemic TgCRND8 Mice Is the Culprit, Not the Consequence