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Critical role for Gab2 in transformation by BCR/ABL

This condition leads to most cases of hypothyroidism (underactive thyroid)

We overexpressed separately the endogenous gene in the first step of the GSH biosynthetic pathway, as well as the gene encoding the bacterial single step multicatalytic enzyme LmgshF and StgshF , under the control of a strong constitutive promoter ( TDH3 )

not yet approved Tirzepatide : FDA-approved as Mounjaro (2022) for T2D and Zepbound (2023) for obesity Advantage : Tirzepatide Side Effect Profile# Retatrutide : GI side effects common

Three additional peptides target fat through different mechanisms
