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Description
Early-stage ferroptotic cells express calreticulin, which, upon binding to the LRP1 receptor on dendritic cells, fosters the phenotypic maturation of bone marrow-derived dendritic cells, eliciting vaccine-like effects in immunocompetent mice
When injected, they can trigger fever, systemic inflammation, or sepsis
Other research investigating gastrointestinal motility has used doses near 1 mg/kg in rodent models to assess effects on gastric emptying and intestinal motility
The washout period allows receptor density to normalise
World J Surg 31: 20812084
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