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The in vitro biological effects of CB-839 have been tested more extensively in multiple myeloma ( CLL is a heterogeneous disease, and the different subtypes of CLL have diverse metabolic requirements
FABP6 primarily handles bile acids and is often reported as metabolically protective (while exhibiting distinct associations in oncology)
Suda A, Umaru BA, Yamamoto Y, Shima H, Saiki Y, Pan Y, et al
, Chloupek, P
The novel imipridone ONC212 induces pronounced anti-leukemia effects in vitro and in vivo and is highly synergistic with the BCL-2 inhibitor ABT-199
Margalit, A., Phalen, H., Gao, C., Ma, J., Surech, K
