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Within the gut UDCA bids to and activates the bile acid receptor, G-protein coupled bile acid receptor 1, GPBAR1 (originally identified as TGR5 and also known as GPR131) to enhance the expression of the proglucagon (GCG) gene in enteroendocrine L-cells resulting in increased production and release of GLP-1

Mitochondrial dysfunction results in increased production of ROS which activates stress responses leading to increased activity of MAPK and JNK

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