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Niacin therapy has been used safely in children for the treatment of nutritional niacin deficiency

Discovery and characterization of nutritionally regulated genes associated with muscle growth in Atlantic salmon
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Pure Appl Chem 1975

Other antioxidants are soluble only in water (like vitamin C), limiting how your body can store and use them

Folic acid, vitamin B6 and vitamin B12 in combination with age-related macular degeneration in a randomized trial of women