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They may also indirectly exert their antioxidant activity by stimulating endogenous antioxidant defense systems (e.g., glutathione peroxidase and superoxide dismutase) and/or inhibiting enzymes that generate large amounts of ROS, such as xanthine oxidase and NAD(P)H oxidase

Disruption of iron metabolism may result in the aberrant buildup of iron inside the cell, which can lead to ferroptosis

Nature 509 , 230234 (2014)

Front Immunol (2020) 11:578952
Impacts of Indoxyl sulfate and p-cresol sulfate on chronic kidney disease and mitigating effects of AST-120

1d) cells suggesting that superior intracellular iron availability combined with low FSP1 expression may specifically prime SCLC for ferroptosis induction
