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Moreover, the combination of differentiation and hypoxia induces even more oxidative stress, possibly because hypoxia induces mitochondrial ROS production and stimulates reductive carboxylation of glutamine, thereby increasing the NADPH demand 28,29

2014;24:R45362

In group 1 (newly diagnosed diabetic group), there was no significant difference between the percentage of insulin-positive islets with pattern 1 and pattern 2 ( p = 0.09) and in insulin-negative islets between the same 2 patterns ( p = 0.80)

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The other 1% is hormones, vitamins, water, salt, enzymes and other important compounds