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Collectively, these findings indicate that patient DhLOs exhibit reduced phase I/II drug-metabolizing enzyme and transporter expression and activity, accompanied by abnormal phenotypic features, compared to normal DhLOs

The primary end-point event (myocardial infarction/stroke) in 305 patients on alogliptin therapy was 11.3% in comparison with placebo (11.8%) (hazard ratio, 0.96

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doi: 10.3389/fimmu.2024.1370658 45 LuJShataerDYanHDongXZhangMQinYet al