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doi: 10.1371/journal.pone.0247060 60 WangSLiZWangXZhangSGaoPShiZ

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Future studies should prioritize (1) isolating and characterizing the active compounds within these botanicals, (2) elucidating their precise molecular targets (e.g., thyroid peroxidase, sodium-iodide symporter, cytokine signaling pathways), and (3) conducting well-designed controlled clinical trials to rigorously evaluate their safety and efficacy in human patients

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Of note, normal rats exhibited a superior sagittal sinus pressure of 24 to 27 mmHg and a portal pressure of 35 mmHg, similar to that of the inferior vena cava, although this was at least 1 mmHg higher in the portal vein

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