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and Henry, Y., Biochimie , 1977, vol

doi: 10.3945/ajcn.110.003483 254 SestiliP.FimognariC

Numerous studies have reported that high concentrations of Cr 6+ compounds contaminate the soil and hinder the germination and growth of many crops as well as economic plant seeds (Cervantes et al., Chromium compounds are heavily influenced by mining, paint manufacturing, petroleum refining, leather tanning, wood preservation, textile manufacturing, pulp processing, and biocide development, and large-scale industrial operations involving chromium lead to extreme environmental pollution (Haider et al., 1 , which far exceeds the allowable maximum chromium threshold concentration of 2 mg L 1 (Adrees et al., 1 (Zayed and Terry, 2 CrO 4 and CaCrO 4 in chrome slag are the main components that pollute the environment (Chapman, 2 of cultivated land in China is contaminated by heavy metals such as chromium (Batley, According to the National Survey Bulletin of the State of Soil Pollution, jointly released by the Department of Environmental Protection and the Department of Land and Resources in 2014, soil in the 14 provinces of the southern China region show higher levels of heavy metal pollution

However, when cancer has developed, the death of malignant cells by treatment with chemotherapeutic drugs and radiation that produce free radicals in the cells, such as hydrogen peroxide and superoxide, mostly depends on their oxidative damage (8)

Memorias do Instituto Oswaldo Cruz 113 , e180057, (2018)

The TCA cycle is coupled to OXPHOS to provide cells with ATP