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10.1096/fj.08-127662 41 LundbergM.Mattsson.ReiserK.HolmgrenA.CurboS

Large-scale retrospective cohort studies reveal that long-term metformin use in COPD patients reduces lung cancer risk by 2835%, likely through AMPK pathway activation, mitochondrial function restoration, and anti-inflammatory effects

Nrf2 activation provides atheroprotection in diabetic mice through concerted upregulation of antioxidant, anti-inflammatory, and autophagy mechanisms

Han JH, Lee YS, Im JH, Ham YW, Lee HP, Han SB, Hong JT

The summary concluded that melatonin is indicated for the following [92]: Insomnia: Immediate release 13 mg, 30 min before bed