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In mouse models, the loss of thioredoxin reductase 2 (Txnrd2) results in an endothelial phenotype that promotes thrombosis, as Txnrd2-deficient mice develop widespread microthrombi in arteries, arterioles, and capillaries, suggesting a systemic tendency toward thrombosis [46]

Chronic inflammation, oxidative stress, and declining cellular energy aren't just aging problems

Nat Geosci 9:116120

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Parts of chromatin and dense granules are excreted from cells by exocytosis to form NETs
