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Supplementation helps restore physiological balance not overload the system

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Early-life lead exposure recapitulates the selective loss of parvalbumin-positive GABAergic interneurons and subcortical dopamine system hyperactivity present in schizophrenia

doi: 10.3389/fpsyt.2019.00892 194 WangYWeiYEdmistonEKWomerFYZhangXDuanJet al

Noradrenergic neurons dwelling in the locus coeruleus are sensitive to various pathological insults and become altered or malfunctional in many neurological disorders, including attention-deficit/hyperactivity disorders, sleep-associated disturbances 591 , congenital central hypoventilation syndrome, depression and anxiety, and in neurodegenerative diseases, including AD and PD 592,593

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