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For PV3-SC8 GPP3+GSH clear structure was observed in the cryo-EM map up to the end of the C-terminus (Gln238), whereas for PV3-SC8 pleconaril+GSH only an additional two residues (Leu236 and Pro237) became ordered upon GSH binding

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showed that proteosome inhibitors bortezomib, carfilzomib, oprozomib (ONX 0912), and immunoproteasome inhibitor ONX 0914 (previously PR-957) reduced B-cell proliferation, immunoglobulin production, and induced apoptosis of activated B-cells (96)

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