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CDKN1A/p21, cyclin dependent kinase inhibitor 1A

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Prior to the development of FOXO4-DRI, research into cellular senescence largely relied on indirect markers of aging, generalized apoptosis pathways, or broad-spectrum senolytic compounds

By month 4, hed lost 28 pounds while gaining muscle mass

Eating too little accelerates muscle loss and nutritional deficiency

The outcome suggested that a transient and limited increase in gut permeability compared with the unregulated breach of the gut barrier function due to the TJ deregulation and epithelial cell apoptosis can rather lead to a dominant regulatory immune response to gut microbiota antigens and to a net anti-inflammatory effect