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For anyone choosing between tirzepatide dosing protocols and liraglutide, the decision comes down to mechanism, efficacy, side effect tolerance, injection frequency, and cost

Its chemical structure is too different from the compounds targeted in standard drug screens

The NNTs for SGLT-2 inhibitors to reduce mortality are truly impressive, although 1 in 7 patients will get an additional genital infection in five years

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For those who want to go deeper: JAMA Psychiatry (2025):- GLP-1 RAs & Mental Health Meta-Analysis: JAMA Psychiatry (2025):- Semaglutide & Alcohol Use Disorder RCT: eClinicalMedicine / The Lancet (2024):- 12-Month Neurological & Psychiatric Outcomes of Semaglutide: APA Monitor (2025):- Mental Health Effects of GLP-1 Drugs (accessible overview): Interesting

Long-term results at 612 months can reach 2030%+ total body weight loss for some patients