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10.3390/antiox7090119 Antioxidants (Basel)
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They have been shown to enhance the expression of the amyloid precursor protein (APP) processing enzyme beta-site APP cleaving enzyme 1 (BACE), thereby promoting A accumulation in patients with AD and various mouse models 54

there were no overall differences in small blood vessel problems such as those found in eyes, nerves, and kidneys between participants from the DPP Lifestyle Change Program and participants who continued to take metformin or took a placebo
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