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When melanocytes are hyperactivated by specific triggers UV radiation, post-inflammatory signals from acne or injury, hormonal changes (especially estrogen and progesterone in melasma), or genetic predisposition they produce excess melanin that accumulates in patches, creating dark spots, uneven tone and visible discolouration

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Consequently, TCM is expected to be a key entry point for developing a multitargeted therapeutic approach to AD (Islam et al., 2022)

Sperm postacrosomal WW domain-binding protein is not required for mouse egg activation

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This process is called reconstitution