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231 found accelerated DNA methylation age in Down syndrome patients with clinical signatures of accelerated ageing. There is also evidence that frailty, a syndrome with a pronounced association with age-related phenotypes, has a significant association with DNA methylation age, but not with telomere length

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These modifications are not random but occur at specific residues such as lysine (K), arginine (R), serine (S), or threonine (T) and accordingly, can alter the accessibility of transcription factors to their binding sites [39,40]

[Google Scholar] Glutathione in plants: biosynthesis and physiological role in environmental stress tolerance

Hirabayashi T, Anjo T, Kaneko A, Senoo Y, Shibata A, Takama H, et al