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However, in a pathological context, tau protein undergoes abnormal hyperphosphorylation, which leads to intracellular tau accumulation and the formation of neurofibrillary tangles in the brain

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Akbarzadeh A, Rezaei-Sadabady R, Davaran S, Joo SW, Zarghami N, Hanifehpour Y et al

[DOI] [PubMed] [Google Scholar] 207.Uddin M.M., Chen Z., Xu F., Huang L

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While we did not evaluate the tight junctions in this study, our results support that changes in astrocyte morphology are sufficient to induce changes in bloodbrain barrier permeability