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The elimination of interferon IFN-g or STAT1 genes in mice resulted in increased incidence and growth of spontaneous and chemically induced tumors (75,77,78)

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Although these experiments had no effects on tumor viability, the concept was later picked up by Wilhelm Brnings 178 , 179 who combined maximally tolerable doses of insulin treatment with a KD into a de-glycation method (Entzuckerungsmethode) for the treatment of head and neck cancer patients in his clinic

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Bettelheim P, Muhm M, Valent P, Geissler K, Andreeff M , Haimi J, Sillaber C, Hinterberger W, Vieder L, Schulz G, et al