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The bioavailability is exceptionally high, approaching 100%
The rationale for combining them is based on mechanistic complementarity (non-overlapping pathways), individual safety profiles, and clinical observations from practitioners administering the combination
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The trial showed that, after 4 years of treatment with nirogacestat, the disease had not progressed in any of the 17 patients in the study
doi: 10.2147/dmso.s205379 48
Loibl, M
