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3.5 Cascading regulation of multidimensional heterogeneity The preceding sections have separately elucidated the mechanistic findings of ferroptosis in gingival epithelial cells, periodontal ligament fibroblasts, osteoblasts, osteoclasts, and macrophages

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Microglia play a crucial role in orchestrating this phenotypic shift: upon activation, they release inflammatory mediators such as IL-1, TNF- and C1q, which induce a pro-inflammatory reactive astrocyte phenotype (often termed A1-like or neurotoxic reactive state) (Zhao et al., 2024

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