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PubMed Central PMCID: PMC3616288

Overall, the data demonstrate that ACLY and ACSS2 are not the sole sources of acetyl-CoA in the nuclear-cytosolic compartment, and that the carnitine shuttle participates in the transit of acetyl-CoA from mitochondria to cytosol to support lipogenesis and histone acetylation

Heres something important though not all L-Carnitine products are the same, and we actually have two options for different needs: L-Carnitine Shot This is my go-to for fat burning and clean, steady energy

This allows it to bypass those restrictive transporters and enter cells directly via diffusion and membrane fusion, achieving significantly higher absorption