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Moreover, DHA, ALA, and EPA treatment of mouse dorsal root ganglion neurons reportedly facilitates the opening of potassium M-channels, dampening neuronal activity [127]

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Additionally, these resistant strains exhibit increased sensitivity to oxidative stress ( FIGURE 2 Further research suggests that resistance mechanisms to AmB in Leishmania involve complex interactions between genetic mutations and metabolic changes

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PXR then forms a complex with the retinoid X receptor (RXR), binds to DNA upstream of target genes, recruits coactivator (which binds to the TATA box binding protein, TBP), and activates transcription by RNA polymerase II (RNAP II)

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Mischoulon and Fava, 2002)

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