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Patients may experience: Persistent fatigue and weakness Breathlessness on exertion Pallor or a slightly yellowish tinge to the skin Heart palpitations Neurological symptoms are of particular clinical concern, as nerve damage caused by prolonged B12 deficiency can be irreversible if not treated promptly

10.1007/s00213-014-3643-x 63
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This is particularly relevant in muscle and cardiovascular research models
[DOI] [PMC free article] [PubMed] [Google Scholar] 3.Kalyanaraman, B

Severe deficiency has been linked to low birth weight, pre-term birth, and megaloblastic anemia
