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doi: 10.1001/jama.2017.21907

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290 Besides, ROS directly activate ASK1 through homo-oligomerization and autophosphorylation at Thr838 or hetero-oligomerization with ASK2, where ASK2 phosphorylates Thr838 of ASK1 after its own autophosphorylation at Thr806 291 (Table 1, Fig

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