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were supported by the Swedish Research Council (VR) (2021-01683), the Swedish Foundation for Strategic Research (ICA16-0050), Jeanssons Foundation (JS2017-0141, JS2018-0034), Clas Groschinskys Minnesfond (M18213, M19351), Svenska Lkaresllskapet (SLS-784981, SLS-960584), and the Karolinska Institute Foundation
