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The broader preclinical record, reviewed exhaustively by Graf and Kastin [4, 5], includes sleep-architecture effects in rats and mice, and predominantly REM-related effects in cats a species-specificity that the delta sleep-inducing name does not capture
E2 and DHT were used as positive controls for the YES and YAS bioassay, respectively, with ethyl acetate serving as the blank control

doi: 10.1038/s41598-022-05667-0

[DOI] [PMC free article] [PubMed] [Google Scholar] 60.Xu B., Zhang M., Shi X., Zhang R., Chen D., Chen Y., Wang Z., Qiu Y., Zhang T., Xu K., et al
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However, regular injections are recommended for ongoing benefits
