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Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease

Notably, it was primarily localized in the kidneys and liver (Liu et al., 2019)

It also upregulates molecular chaperones and components of the proteostasis network, such as heat shock proteins (HSP60, HSP70) and autophagy-related proteins, facilitating the removal of toxic protein species (75)

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