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While proliferation significantly contributes to distal tumor growth, it is important to note that additional processes that the IGF pathway regulates in primary tumors, such as cancer stemness, EMT and invasion, also likely shape the successful establishment of secondary metastatic tumors

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In addition, under cold stress, both mutants showed a lower expression of C-repeat binding factor/dehydration responsive element binding1 (CBF/DREB1) compared with the wild-type plants, while the expression of AtGLR1.2-OE [ AtGLR1.2-GFP (green fluorescence protein)] and AtGLR1.3-OE [ AtGLR1.2-GFP ] was upregulated in transgenic plants (Zheng et al., 2018)

Future advances in overcoming these challenges may unlock substantial therapeutic prospects across various stem cell platforms, enabling personalized regenerative strategies tailored to specific pathological contexts (129131)

The accumulation of AGEs is known to be linked with IR and the aging process, which has the potential to hinder folliculogenesis and diminish endometrial receptivity

These preclinical models provide the possibility of using a control and treatment groups experimental design, drug interventions, induction of AGIHL and the objective measurement of the hearing function