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Given 40-60% nasal bioavailability compared to 80-95% for injection, equivalent nasal doses would be approximately 400-1000mcg to achieve similar systemic levels

[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Jose S., Hughbanks M.L., Binder B.Y.K., Ingavle G.C., Leach J.K

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However, long-term activation of an opioid receptor with either chronic use or abuse of opioids leads to highly undesirable and clinically significant side effects

Transl Lung Cancer Res (2014) 3:4035
