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doi: 10.1002/jcph.371

Furthermore, putrescine levels, a substrate for MAOB-mediated GABA synthesis, 33 were significantly elevated in PTSD-like mice (Supplementary Fig

10.1016/j.heliyon.2019.e01572 29 JesulolaE.MicalosP.BaguleyI

That is, a genetic predisposition, an environmental injury (e.g., surgical trauma), and psychological distress can converge and synergistically drive maladaptive neuroplasticity and disrupt homeostatic systems, thereby facilitating the transition from acute nociception to a persistent chronic pain state

This inhibitory effect is mediated by a rise in cGMP levels in platelets, which lowers intracellular calcium concentrations required for platelet activation (Liu and Huang, 2008