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Protein domain enrichment analysis identified significant enrichement of domains such as nucleophile aminohydrolases, EF-hand domains, and histone-fold domains, reflecting their critical roles in enzymatic activity, calcium signaling, and chromatin dynamics (Fig

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Therefore, we asked whether we could rescue glutamine dependency of KPK cells by forcing the export of cystine and the import of glutamate by modulating the concentration of these two amino acids in the culture media

Furthermore, the amount of Ca 2+ released from the endoplasmic reticulum plays an important role in regulating apoptosis, as it signals the mitochondria, modulating autophagy suggesting a complex interplay between these pathways and necrosis, especially excitotoxicity-induced necrosis (Hyer-Hansen et al., 2007