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glutathione and stress Oxidative stress, glutathione, CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models Glutathione-responsive oxidative stress nanoamplifier boosts
Description
[DOI] [PubMed] [Google Scholar] 7.Brown C.J., Mackinnon S.E., Evans P.J., Bain J.R., Makino A.P., Hunter D.A., Hare G.M

Authorship Contributions Sandro Gentile and and Felice Strollo prepared and wrote the paper

Inhibiting this system, either pharmacologically or genetically, leads to glutathione depletion, promoting LPO and cell death via ferroptosis [135]

Clinically improves the appearance of uneven skin tone at 4 weeks*

Cellular damage in DILI can reflect toxic effects of the culprit medication or its metabolites, or immune-mediated effects (Figure 1)
doi:10.1073/pnas.2413811122
