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glutathione and stress Oxidative stress, glutathione, CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models Glutathione-responsive oxidative stress nanoamplifier boosts

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[DOI] [PubMed] [Google Scholar] 7.Brown C.J., Mackinnon S.E., Evans P.J., Bain J.R., Makino A.P., Hunter D.A., Hare G.M

glutathione and stress Oxidative stress, glutathione, CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models Glutathione-responsive oxidative stress nanoamplifier boosts

Authorship Contributions Sandro Gentile and and Felice Strollo prepared and wrote the paper

glutathione and stress Oxidative stress, glutathione, CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models Glutathione-responsive oxidative stress nanoamplifier boosts

Inhibiting this system, either pharmacologically or genetically, leads to glutathione depletion, promoting LPO and cell death via ferroptosis [135]

glutathione and stress Oxidative stress, glutathione, CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models Glutathione-responsive oxidative stress nanoamplifier boosts

Clinically improves the appearance of uneven skin tone at 4 weeks*

glutathione and stress Oxidative stress, glutathione, CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models Glutathione-responsive oxidative stress nanoamplifier boosts

Cellular damage in DILI can reflect toxic effects of the culprit medication or its metabolites, or immune-mediated effects (Figure 1)

glutathione and stress Oxidative stress, glutathione, CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models Glutathione-responsive oxidative stress nanoamplifier boosts

doi:10.1073/pnas.2413811122

glutathione and stress Oxidative stress, glutathione, CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models Glutathione-responsive oxidative stress nanoamplifier boosts

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