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Together, these data support a model in which adoptively transferred splenocytes from aged mice initiate a systemic inflammatory cascade, which in turn activates and expands endogenous tissue-resident macrophages, leading to sustained tissue functional impairment

It is noteworthy that an intriguing animal study demonstrated that CGRP preferentially activates and sensitizes trigeminal nociceptors in the dura of female mice, but not male mice [111]

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Sifers, Brashears-Macatee, Kidd, Muensch, & Woo, 1988

[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Demirta H, zer A, Yldrm AK, Dursun AD, Sezen C, Arslan M