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Wild-type TTR amyloidosis primarily affects the heart, and although often asymptomatic, amyloid deposits can be detected in approximately 25% of men over 80 years of age [5], making TTR amyloidosis one of the most common amyloid disorders

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Although dietary lipids encompass triacylglycerols, phospholipids, sterols (predominantly cholesterol with minor phytosterols), and small amounts of free fatty acids 10,11 only fatty acyl chains are oxidizable for yielding energy, whereas cholesterol is catabolized chiefly to bile acids rather than used as an energy substrate 12