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Those with normal absorption can be maintained on oral replacement

However, one study presented conflicting results in mice, reporting a current-dependent increase in the firing rates of L5p following DOI application (2050 nA) (De Gregorio et al., 2021)

The mechanism proceeds as follows: Mitochondrial Disruption: The KLAKLAK sequence disrupts the outer mitochondrial membrane, causing cytochrome c release and depolarizing the membrane potential

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Selenium was able to maintain the anti-oxidative stress function of glutathione peroxidation and selenoprotein P (49)