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In models of epilepsy, the expression of STAT3 and p-STAT3 are up-regulated, p-STAT3 was translocated into nucleus acts as a dual-target transcription factor that binds to the promoters of Nlrp3 and Trpm7 thereby resulting in the increased expression of NLRP3 and TRPM7

High-dose oral cyanocobalamin (1,000 mcg daily) is effective for many patients after sleeve gastrectomy, as a small proportion is absorbed passively without intrinsic factor

2 Watson NF, Buchwald D, Goldberg J, Noonan C, Ellenbogen RG

Fatigue can lead to a cascade of compensatory movements and muscle activation patterns that exacerbate the strain on the ACL

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