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Inhibition of -oxidation, mitochondrial dysfunction, and insulin resistance (IR) are the three most important links in these hits as well as targets for carnitine to ameliorate NAFLD

Ultimately, this work opens therapeutic avenues not only for LC-FAODs but also for a wide range of metabolic and neuromuscular disorders where energy failure is central to disease pathogenesis

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Tachikawa M, Takeda Y, Tomi M, Hosoya K

Results: We found marked neuronal alterations in the cortex and hippocampus of LPS intoxicated animals associated with higher inflammatory cytokines expression cyclooxygenase (COX2), tumor necrotic factor-alpha (TNF-)

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