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A double negative feedback loop between mTORC1 and AMPK kinases guarantees precise autophagy induction upon cellular stress

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Indeed, previous studies exploring mitochondrial S-nitrosylation and cellular signaling have demonstrated that significantly different, and often much lower, concentrations of NO donors can be biologically active depending on the specific cellular or subcellular system employed 44,45

[PubMed: 701454] 579

As a result, some believed that the pineal calcification might be a physiological process and not associated with pathological or aging changes

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