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Developmental and osteoarthritic changes in Col6a1 knockout mice: biomechanics of type VI collagen in the cartilage pericellular matrix

More than 55% of pregnancies in the United Kingdom occur in women who are overweight or living with obesity

All participants received a standardized lifestyle intervention, which included counseling on a reduced-calorie diet (500 kcal/day deficit) and increased physical activity ( 150 min/week) in addition to study drug or placebo

Side effect management GLP-1 medications carry a well-documented side effect profile

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Finally, KGMs promotion of beneficial bacteria offers systemic benefits, as its ability to proliferate Akkermansia muciniphila in HFD murine models enhances insulin sensitivity and reduces systemic inflammation [72,104]