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Genetic studies were assessed for quality using the Newcastle Ottawa Scale plus additional criteria that included consideration of Hardy Weinberg equilibrium, power of the study, population stratification and correction for multiple comparisons

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NRF2 is subsequently stabilized to transcriptionally upregulate antioxidant response genes including xCT, the rate-limiting enzyme in glutathione synthesis, glutamate cysteine ligase (GCL), and enzymes used in detoxification of ROS, such as GPx [42], to attenuate ROS damage

PMID 22990615

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