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In a study published by Russian researchers Ivanikov et al

Wolters Kluwer Health, 2015

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They found that under basal conditions without Mn 2+ supplementation, endogenous labile Mn 2+ is confined to sparse punctate foci, consistent with a compartmentalized intracellular pool

Therefore, the aim of therapy is to target albumin-bound non-ceruloplasmin free copper, which is toxic

Gut 55 , 342347 (2006)