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Diabetes Care 43 , 27852795 (2020)

A larger clinical trial randomly assigned more than 500 patients with type 2 diabetes and symptomatic peripheral neuropathy to one of the following treatments: (i) 600 mg/day of intravenous lipoic acid for three weeks followed by 1,800 mg/day of oral lipoic acid for six months, (ii) 600 mg/day of intravenous lipoic acid for three weeks followed by oral placebo for six months, or (iii) intravenous placebo for three weeks followed by oral placebo for six months (76)

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We observed a significant upregulation in IL-10 levels and significant downregulation of TNF-, IL-6, and IL-1 in GGC-treated cells, suggestive of the beneficial effects of GGC against oligomeric A 40 -induced neuroinflammatory response